Arsenal, currently second in the Premier League, have started the season strongly. The Gunners have accumulated 10 points from their first four matches, recording three wins and a draw, building on last season's second-place finish.
Atalanta, meanwhile, have experienced a mixed start to their Serie A campaign. Gian Piero Gasperini's men have secured two victories but also suffered two defeats, leaving them in ninth place in Italy's top flight. The Bergamaschi will look to use home advantage as they aim to make a statement against one of England's top clubs.
In other Champions League action, defending champions Real Madrid began their title defense in emphatic fashion, defeating Stuttgart 3-1 on Tuesday.