Barcelona, meanwhile, started their season with an underwhelming goalless draw against Getafe, but they have since beaten both Cadiz and Villarreal to move onto seven points in the table.
Xavi's side were involved in a seven-goal thriller away to Villarreal last Sunday; the visitors led 2-0 in the opening 15 minutes courtesy of goals from Gavi and Frenkie de Jong before conceding three times either side of the half-time interval to trail to the Yellow Submarine.Ferran Torres made it 3-3 in the 68th minute, though, before Robert Lewandowski netted the winner in the 71st minute, with Barcelona picking up a vital win to stay in touch with leaders Real Madrid early in the season.
Barcelona comfortably won the La Liga title last season, finishing 10 points clear of second-placed Real Madrid, but it would be a surprise to see them that far clear this term.
The club's financial problems have made it a difficult summer transfer window to navigate, but loan deals for Joao Cancelo and Joao Felix went through on Friday, with the two players set to be valuable additions to a squad which is certainly in need of a boost.
Osasuna will again be without the services of Darko Brasanac due to a long-term knee injury, but the home side are otherwise in strong shape ahead of the contest.
Ezequiel Avila will return to the squad, having served his suspension against Valencia, while there are expected to be changes to the side that started against Club Brugge on Thursday.
Aimar Oroz, Jesus Areso, Kike Barja and Ruben Garcia are in line for returns to the side, but the likes of Sergio Herrera and David Garcia will retain their positions in the starting XI.
Barcelona, meanwhile, could potentially have Cancelo and Felix in their squad, with the loan deals for both players being completed on Friday night.
Raphinha is back from a suspension and should return to the side, but Ronald Araujo and Pedri remain on the sidelines through injury.
Inigo Martinez is also a major doubt due to an ongoing foot problem, with the centre-back unlikely to be risked ahead of the international break.
Head coach Xavi has decisions to make when it comes to his team selection, but there should be another start for Lamine Yamal, who starred against Villarreal last time out, with Gavi potentially being the player to drop down to the bench to allow Raphinha to come in.
